Phospholipase C

  1. 神経伝達物質
  2. Phospholipase C

The phospholipase C (PLC1) is an enzyme that catalyzes the decomposition of phospholipids. It catalyzes the decomposition of PIP2 (phosphatidyl-inositol 4,5 biphosphate) to IP3 (1,4,5 inositol-tri-phosphate) and DAG (di-acyl-glycerol). In turn, DAG phosphorylate PKC (Protein Kinase C) and works synergistic with Ca2+ released from ER (endoplasmic reticulum) by IP3.


The Cleavage Sites of Phospholipases


Phosphatidyl-Inositol 4,5 biPhosphate (PIP2)